Tirzepatide is a new dual receptor agonist drug, which is currently mainly used for the following purposes:
1. Obesity/overweight management
Effects:
It promotes weight loss by suppressing appetite, delaying gastric emptying, reducing calorie intake.
It is more effective than traditional GLP-1 drugs (such as semaglutide).
Clinical effects:
The SURMOUNT series of trials showed that the average weight loss of obese patients (without diabetes) was:
15%-20% (5 mg/week)
20%-22% (10-15 mg/week)
Significantly improved metabolic indicators such as waist circumference, blood lipids, and blood pressure.
Applicable population:
Obese (BMI ≥ 30 kg/m²) or overweight (BMI ≥ 27 kg/m²) with at least one obesity-related disease (such as hypertension, type 2 diabetes, dyslipidemia).
2.2 type diabetes
Effects:
As an adjunct to diet and exercise, it improves blood sugar control.
It activates GIP and GLP-1 receptors, improves insulin sensitivity, inhibits glucagon, and slows gastric emptying, thereby reducing fasting and postprandial blood sugar.
Clinical effects:
Significantly reduces HbA1c (glycosylated hemoglobin) by 1.8%-2.4%.
Some patients can achieve weight loss during treatment (additional benefit).
Applicable population:
Adult patients with type 2 diabetes, especially those with obesity or overweight combined with diabetes.
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