Product
Active ingredient: Mazdutide
Product category
1.Dual-target agonists:
Dual agonists of GLP-1 receptor (glucagon-like peptide-1) and GCGR receptor (glucagon receptor).
2.Indications:
Blood glucose control in type 2 diabetes mellitus (T2DM)
Obesity/Overweight management (approved in some countries or regions)
Pharmacological mechanism:
Mazdutide achieves therapeutic effects through the following dual actions:
1.GLP-1 receptor activation: Promotes insulin secretion, inhibits glucagon release, and lowers blood sugar. Delay gastric emptying and increase a feeling of fullness.
2.GCGR receptor activation: Enhances energy expenditure, promotes fat metabolism, and improves hepatic gluconeogenesis.
Product advantages：
1.Dual targets: Compared with single GLP-1 drugs (such as semaglutide), additional activation of the GCGR receptor may bring about more significant weight loss and metabolic improvement effects.
2. Long-term effectiveness: Subcutaneous injection once a week to enhance patient compliance.
3. Comprehensive metabolic benefits: In addition to lowering blood sugar, it can also reduce blood lipids, reduce weight, and improve non-alcoholic fatty liver disease (NAFLD), etc.
4. Hypoglycemic effect: In patients with type 2 diabetes, HbA1c (glycated hemoglobin) is significantly reduced (clinical trials show a decrease of 1.5% to 2.0%).
5. Weight loss effect: The average weight loss for obese patients can reach 10% to 15% (high-dose group).
6. Safety: Common adverse reactions include mild to moderate gastrointestinal reactions (such as nausea and diarrhea), which are similar to those of similar drugs.
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